In Silico characterization of STK11- a protein involved in PJ Syndrome
نویسندگان
چکیده
Studies of hereditary cancer syndromes have contributed greatly to our understanding of molecular events involved in tumor genesis. One such syndrome of our interest is Peutz-Jeghers Syndrome, a hereditary disease, in which there is predisposition to benign and malignant tumors of many organ systems. Here, we investigate the genes responsible for the Peutz-Jeghers syndrome (PJS) and the pathway of disease causing mechanism. The STK11, Serine/Threonine Kinase 11, commonly known as LKB1 is the gene responsible for this syndrome. This gene is coding a protein of length 433 amino acids, 48.6 kDa. The protein sequence is retrieved from the protein database of NCBI. The analysis of this protein is performed using various in silico methods.
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